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NCI Patient-Derived Models Repository (PDMR) - An NCI Precision Oncology Initiative Resource
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Last Updated: 05/11/22

NCI Repository Publications

Publications

Title Year Journal
Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts 2021 Nature Genetics
Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment 2021 Nature Communications
Systematic Establishment of Robustness and Standards in Patient-Derived Xenograft Experiments and Analysis 2020 Cancer Research
A Spontaneously Metastatic Model of Bladder Cancer: Imaging Characterization 2019 Journal of Translational Medicine
PDX-MI: Minimal information for patient-derived tumor xenograft models 2018 Cancer Research

Meeting Posters/Presentations

Title Year Meeting
Method development for generation of PDX models from rapid autopsy samples for the NCI Patient-Derived Models Repository 2022 AACR
Genomic characterization of PDX models from rare cancer patients in the NCI Patient-Derived Models Repository 2022 AACR
Quality control workflows developed for the NCI Patient-Derived Models Repository using low pass whole genome sequencing and whole exome sequencing 2022 AACR
Comparative single cell transcriptome profiling of BL0293 PDX primary tumors, CTCs, and metastatic sites 2022 AACR
Patient-derived organoid drug responses corroborate known target-drug interactions for selected anticancer agents 2022 AACR
Patient-derived models of rare cancers in the National Cancer Institute's Patient-Derived Models Repository (PDMR) 2021 AACR
Single agent response comparisons in a large-scale, preclinical trial of rare cancer PDXs by the National Cancer Institute's Patient-Derived Models Repository (PDMR) 2021 AACR
Applications of immunohistochemistry in characterization of patient derived xenograft models 2021 AACR
Imaging Characterization of NCI Patient Derived Models Repository (PDMR) xenografts 2021 AACR
Study of tumor heterogeneity and subclonality in primary pancreatic and metastatic sites from rapid autopsy patients in PDMR 2021 AACR
Quality control efforts in a large-scale, preclinical trial of rare cancer PDXs by the National Cancer Institute’s Patient-Derived Models Repository (PDMR) 2020 AACR
Patient-derived organoid and cell culture models from the NCI Patient-Derived Models Repository (NCI PDMR) preserve genomic stability and heterogeneity of patient tumor specimens 2020 AACR
Genomic landscape of acquired uniparental disomy in NCI PDMR patient-derived xenograft models 2020 AACR
Evaluation of patient-derived cell lines and cancer organoids for the prediction of drug responses in patient-derived xenograft models 2020 AACR
Integrative analyses of signaling and DNA damage repair pathways in patient-derived xenograft (PDX) models from NCI’s Patient-Derived Models Repository (PDMR) 2019 ASCO
Comparison of genomic biomarkers identified by the whole exome, RNASeq and whole genome sequencing pipelines developed for the PDMR 2019 AACR
Xenograft-associated B cell lymphoproliferative disease as a surrogate model to study Epstein-Barr Virus (EBV) driven lymphoma of the elderly 2019 AACR
Comparison of PDX, PDC, and PDOrg models from the National Cancer Institute's Patient-Derived Models Repository (PDMR) 2019 AACR
PDX models generated from a patient with metastatic colon adenocarcinoma display both spatial and temporal tumor heterogeneity 2018 AACR
Xenograft-associated B cell lymphoproliferative disease as a surrogate model to study Epstein-Barr Virus (EBV) driven lymphoma of the elderly 2018 AACR
The National Cancer Institute’s Patient-Derived Models Repository (PDMR) 2018 AACR
Assessment of the Genomic Stability and Molecular Landscape of Patient-Derived Xenograft (PDX) Models from NCI’s Patient-Derived Models Repository (PDMR 2018 ASCO
Establishing a platform for the generation of organoids from diverse tumor types as part of the NCI Patient-Derived Models (PDM) initiative 2017 AACR
The National Cancer Institute’s Patient-Derived Models Repository (PDMR) 2017 AACR
NCI's Patient-Derived Models Repository: Generating models from racial and ethnic minorities 2017 AACR-Cancer Health Disparities
Individual ancestry estimation from whole exome sequencing data in patient-derived xenograft samples 2017 Genome Informatics, CSHL
Clonal heterogeneity in patient-derived xenografts: The neuroendocrine PDX model BL0479 contains stable clones with epithelial or mesenchymal characteristics and differential drug sensitivities 2015 AACR
Cell sorting strategies for the isolation of cancer cells and associated fibroblasts from tumor biopsies, surgical resections and patient-derived xenografts 2015 AACR